Neural interface laboratories / Experimental series 02
Biohybrid Neural Interface Laboratory
An engineered living bridge between electronics and neural tissue.
Active branched cables · canonical Hodgkin–Huxley at 6.3 °C · synthetic morphology. Electrical behavior is calculated; graft-specific biology is uncalibrated.
Follow electrical stimulation through the active graft cable, a conductance synapse, and the receiving host.
Drag to orbit · right-drag to pan · scroll to zoom. Select a compartment for its trace. Neurite widths ×2; coordinates and scale retain physical dimensions.
What makes the bridge work?
Test a complete causal chain with matched controls, or vary one physical parameter across a finite grid. Every condition runs the active compartment model; a visible electrode waveform alone does not establish host recruitment.
Loads two graft and three host cells in a 300 µm bridge with near-host stimulation. After the main calculation completes, run the matched audit to inspect which host responses depend on the junction.
Complete the main experiment to establish a reproducible base.
Start with the matched audit. Compare host recruitment with its synapses-off control, then inspect the separated graft and host source signals.
A nonzero receiving-electrode signal with zero host spikes can be volume-conducted graft activity. The calculation must distinguish those outcomes.
Growth & integration
A seeded exploratory model follows extension, turning, branching, target encounters and candidate synapses over days. Contact and functional transmission remain separate assumptions.
Whether a defined excitable cable conducts, whether assigned host–graft synapses recruit receiving cells, and how electrode geometry changes ideal signals. Meaningful physical parameters recalculate those outcomes.
Morphology, synaptic strengths and the electronic bridge are representative assumptions. Published micro-TENN and cortical engraftment experiments motivate the architecture; they do not calibrate these thresholds, growth outcomes or chronic performance. Read the evidence register.