Laser-pulled nanotube probe with a nano optical fibre as the light channel inside and iridium oxide as the electrical channel outside, plus a total-internal-reflection layer that removes the photoelectric artifact. Intracellular recording and light stimulation in hippocampal neuron cell-line experiments. Liu Jingquan's group at Shanghai Jiao Tong University (ACS Nano 2024).
Catalog specification sheet - Other
SJTU opto-electrophysiology nanotube probe with total-internal-reflection layer
Independent, source-linked catalog sheet. Not a manufacturer-issued datasheet, regulatory decision or instructions for clinical use. Human evidence does not establish approval. Source-specific restrictions, conflicts and missing specifications are retained below.
SJTU opto-electrophysiology nanotube probe
A single-neuron probe that stimulates with light and records electrical signals from the same nanometer-scale tip. From Liu Jingquan’s team at Shanghai Jiao Tong University. Paper: “An opto-electrophysiology neural probe with photoelectric artifact-free for advanced single-neuron analysis”, ACS Nano 2024, DOI 10.1021/acsnano.4c07379 (PMID 39193830). The source is SJTU’s Chinese release of 7 September 2024. The paper text was not read, so dimensions and impedance are blank. The tests were on cultured mouse hippocampal neuron cell lines, not in a living animal.
Identity
Field
Value and source scope
Device
Opto-electrophysiology neural probe [1][2]
Origin
Shanghai Jiao Tong University, Liu Jingquan group [1]
Multilayer nanotube; nano optical fibre as the light channel on the inner layer, iridium oxide as the electrical channel on the outer layer, both at the tip [1]
Artifact control
Total-internal-reflection (TIR) layer; simulation showed 50% higher electric field in the light channel and almost no light leakage into air [1]
Tip diameter, tube dimensions
Materials and fabrication
Field
Value and source scope
Process
Laser-assisted pulling plus micro-nano fabrication [1]
Materials
Optical fibre, iridium oxide; other layers blank [1]
Performance envelope
Field
Value and source scope
Cell damage
Higher rate of undamaged cells than a tapered optical fibre; the membrane fully wraps the electrode tip on insertion with no change in intracellular material or activity [1]
Light delivery
By adjusting tip diameter the probe lights up fluorescence in one neuron or a local group; emission spectrum recorded across 380 to 750 nm with the dual light channel [1]
Artifact
With a 10 Hz light source, background noise showed no difference with and without light, with similar normal-distribution noise statistics; power spectral density matched noise level [1]
Limits
Cell-line work only. The same group’s related nanopipette, with an in situ Ag/AgCl reference electrode and tip size 400 to 800 nm, reduced pH measurement error by 0.047 to 0.055 in cell experiments (Biosensors and Bioelectronics 2024, SJTU release of 20 March 2024); that is a separate cell-analysis device and has no sheet here.